In the Sierra de Salamanca, vineyards have been cultivated since Roman times. For centuries, the region's winegrowers have reclaimed land from the mountains to cultivate vineyards on terraces. Today, this area stands out for its great beauty and the complexity of its terroir. The vineyards grow on terraces above the Alagón River and feature a high percentage of very old vines.
Since 2010, the DOP Sierra de Salamanca has protected the typicity of the wines produced by six wineries committed to the value of the rufete grape. The geographical area of the D.O.P. Vino de Calidad de Sierra de Salamanca is located in the south of the province of Salamanca and covers an area of 482.10 km². Part of the production area lies within the Las Batuecas–Sierra de Francia Natural Park, and the entire region is part of the Sierras de Béjar – Francia Biosphere Reserve.
The D.O.P. includes 26 municipalities: Cepeda, Cristóbal, El Cerro, El Tornadizo, Garcibuey, Herguijuela de la Sierra, Lagunilla, Las Casas del Conde, Los Santos, Madroñal, Miranda del Castañar, Mogarraz, Molinillo, Monforte de la Sierra, Montemayor del Río, Pinedas, San Esteban de la Sierra, San Martín del Castañar, San Miguel de Valero, Santibáñez de la Sierra, Sequeros, Sotoserrano, Valdefuentes de Sangusín, Valdelageve, Valero, and Villanueva del Conde.
The rufete is the native and predominant variety in this region. Other varieties, such as garnacha tinta and tempranillo, are also cultivated, known locally as calabrés and aragonés, respectively.